MUC1 cDNA ORF Clone, Human, C-HA tag

Cat: HG12123-CY
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MUC1 cDNA ORF Clone, Human, C-HA tag General Information
NCBI Ref Seq
RefSeq ORF Size
795 bp
Full length Clone DNA of Human mucin 1, cell surface associated, transcript variant 2 with C terminal HA tag.
Enhanced CMV promoter
Tag Sequence
Sequencing Primers
Quality Control
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

MUC1 cDNA ORF Clone, Human, C-HA tag Alternative Names
ADMCKD cDNA ORF Clone, Human;ADMCKD1 cDNA ORF Clone, Human;CA15-3 cDNA ORF Clone, Human;CD227 cDNA ORF Clone, Human;EMA cDNA ORF Clone, Human;H23AG cDNA ORF Clone, Human;KL-6 cDNA ORF Clone, Human;MAM6 cDNA ORF Clone, Human;MCD cDNA ORF Clone, Human;MCKD cDNA ORF Clone, Human;MCKD1 cDNA ORF Clone, Human;MUC-1 cDNA ORF Clone, Human;MUC-1/SEC cDNA ORF Clone, Human;MUC-1/X cDNA ORF Clone, Human;MUC1/ZD cDNA ORF Clone, Human;Mucin 1 cDNA ORF Clone, Human;PEM cDNA ORF Clone, Human;PEMT cDNA ORF Clone, Human;PUM cDNA ORF Clone, Human
MUC1 Background Information

Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
mucin 1, cell surface associated
  • Brayman M, et al. (2004) MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2: 4.
  • Schroeder J A, et al. (2001) Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276 (16): 13057-64.
  • Li Y, et al. (2001) The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 276 (38): 35239-42.
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