MTOR cDNA ORF Clone, Human, C-OFPSpark® tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human mechanistic target of rapamycin (serine/threonine kinase) with C terminal OFPSpark / RFP tag.
Enhanced CMV promoter
HindIII + NotI (6kb + 8.34kb)
OFPSpark Tag: GATAGCACTGAG……CACCTGTTCCAG
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
MTOR cDNA ORF Clone, Human, C-OFPSpark® tag Validated Images
MTOR cDNA ORF Clone, Human, C-OFPSpark® tag Alternative Names
FRAP cDNA ORF Clone, Human;FRAP1 cDNA ORF Clone, Human;FRAP2 cDNA ORF Clone, Human;RAFT1 cDNA ORF Clone, Human;RAPT1 cDNA ORF Clone, Human;SKS cDNA ORF Clone, Human
MTOR Background Information
The protein encoded by MTOR gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
mechanistic target of rapamycin (serine/threonine kinase)
Zhao J, Zhai B, Gygi SP, Goldberg AL. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(52):15790-15797.