CSEN cDNA ORF Clone, Human, C-HA tag

Cat: HG14683-CY
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CSEN cDNA ORF Clone, Human, C-HA tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
771 bp
Description
Full length Clone DNA of Human Kv channel interacting protein 3, calsenilin with C terminal HA tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-HA
Tag Sequence
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CSEN cDNA ORF Clone, Human, C-HA tag Alternative Names
CSEN cDNA ORF Clone, Human;DREAM cDNA ORF Clone, Human;KCHIP3 cDNA ORF Clone, Human
CSEN Background Information

CSEN, also known as calsenilin and KCNIP3, is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS.

Full Name
Kv channel interacting protein 3, calsenilin
References
  • Buxbaum J.D., et al.,(1998), Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat. Med. 4:1177-1181.
  • Carrion A.M., et al., (1999), DREAM is a Ca2+-regulated transcriptional repressor.Nature 398:80-84.
  • An W.F., et al.,(2000), Modulation of A-type potassium channels by a family of calcium sensors.Nature 403:553-556.
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