IL21 Protein, Human, Recombinant

Cat: GMP-10584-HNAE
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IL21 Protein, Human, Recombinant Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 10 EU per mg protein as determined by the LAL method.
Activity
Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells.
The ED50 for this effect is 0.4-2 ng/mL.
Protein Construction
A DNA sequence encoding the mature form of human IL21 isoform 1 (Q9HBE4-1) (Gln23-Ser155) was expressed and purified with an initial Met.
Reference#
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met
Molecule Mass
The recombinant human IL-21 consists of 134 amino acids and has a calculated molecular mass of 15.6 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IL21 Protein, Human, Recombinant in SDS-PAGE
Human IL21/IL-21 Protein 14105
IL21 Protein, Human, Recombinant Alternative Names
CVID11 Protein, Human;IL-21 Protein, Human;Za11 Protein, Human
IL21 Background Information

IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation)

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 21
References
  • Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.
  • Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10.
  • Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4 Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.
  • Other IL21 Proteins

    Canine IL21 Proteins

    Product Name Cat.No.
    IL21 Protein, Canine, Recombinant 70016-DNAE

    Rat IL21 Proteins

    Product Name Cat.No.
    IL21 Protein, Rat, Recombinant (His Tag) 80200-R08B

    Mouse IL21 Proteins

    Product Name Cat.No.
    IL21 Protein, Mouse, Recombinant 50137-MNAE

    Human IL21 Proteins

    Product Name Cat.No.
    IL21 Protein, Human, Recombinant 10584-HNAE
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