gp120 Protein & Antibody

Human Immunodeficiency Virus type 1 (HIV-1) gp120 Protein

gp120 Products

gp120 Protein, Recombinant

Molecule	Species	Description	Cat. No
gp120	HIV-1	Human Immunodeficiency Virus type 1 (HIV-1) gp120 Protein, Recombinant	11233-V08H

  11233-V08H:  Measured by its ability to bind with human CD4 in a functional ELISA.

gp120 Antibody

Molecule	Application	Description	Cat. No
HIV-1 gp120	WB, ELISA	HIV-1 gp120 Antibody, Rabbit MAb	11233-R011
HIV-1 gp120	WB, ELISA	Rabbit Polyclonal Antibody	11233-RP01
HIV-1 gp120	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11233-RP02

gp120 Related Areas

Virus Research Tools>>HIV-1 gp120

gp120 Alternative Names

gp120, HIV-1 gp120, HIV gp120, HIV1 gp120, Surface glycoprotein 120, Surface glycoprotein gp120

gp120 Background

The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.

gp120 Related Studies

1. Kadow J, et al. (2006) Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: an emerging opportunity for drug development. Curr Opin Investig Drugs. 7(8): 721-6.
2. Stevceva L, et al. (2007) Immune responses to HIV Gp120 that facilitate viral escape. Curr HIV Res. 5(1): 47-54.
3. Yoon V, et al. (2010) The GP120 molecule of HIV-1 and its interaction with T cells. Curr Med Chem. 17(8): 741-9.