IGFBP-3 qPCR Primer Pairs, Human

Cat: HP100460
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All IGFBP-3 Reagents
CRO Services
Product recommended

All IGFBP-3 Reagents
IGFBP-3 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
IGFBP-3 qPCR Primer Pairs, Human Alternative Names
BP-53 qPCR Primer Pairs, Human;IBP3 qPCR Primer Pairs, Human;IGFBP3 qPCR Primer Pairs, Human
IGFBP-3 Background Information

The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signalling appears to require an active transforming growth factor beta (TGF-beta) signalling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signalling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.

Full Name
insulin-like growth factor binding protein 3
References
  • Baxter RC. (2001) Signalling pathways involved in antiproliferative effects of IGFBP-3: a review. Mol Pathol. 54(3): 145-8.
  • Butt AJ, et al. (2001) IGFBP-3 and apoptosis--a license to kill? Apoptosis. 6(3): 199-205.
  • Ali O, et al. (2003) Epidemiology and biology of insulin-like growth factor binding protein-3 (IGFBP-3) as an anti-cancer molecule. Horm Metab Res. 35(11-12): 726-33.
  • Yamada PM, et al. (2009) Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. Am J Physiol Cell Physiol. 296(5): C954-76.
  • IGFBP-3 qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    IGFBP-3 cDNA ORF Clone in Cloning Vector, Rhesus CG90084-G
    IGFBP-3 cDNA ORF Clone, Rhesus, untagged CG90084-UT
    IGFBP-3 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90084-ACG
    IGFBP-3 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90084-ACGLN
    IGFBP-3 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90084-ACR
    IGFBP-3 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90084-CF
    IGFBP-3 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90084-NF
    IGFBP-3 cDNA ORF Clone, Rhesus, C-His tag CG90084-CH
    IGFBP-3 cDNA ORF Clone, Rhesus, N-His tag CG90084-NH
    IGFBP-3 cDNA ORF Clone, Rhesus, C-HA tag CG90084-CY
    IGFBP-3 cDNA ORF Clone, Rhesus, N-HA tag CG90084-NY
    IGFBP-3 cDNA ORF Clone, Rhesus, C-Myc tag CG90084-CM
    IGFBP-3 cDNA ORF Clone, Rhesus, N-Myc tag CG90084-NM

    IGFBP-3 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    IGFBP-3 cDNA ORF Clone in Cloning Vector, Human HG10430-M
    IGFBP-3 cDNA ORF Clone, Human, untagged HG10430-UT
    IGFBP-3 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10430-ACGLN
    IGFBP-3 cDNA ORF Clone, Human, C-GFPSpark® tag HG10430-ACG
    IGFBP-3 cDNA ORF Clone, Human, C-OFPSpark® tag HG10430-ACR
    IGFBP-3 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10430-CF
    IGFBP-3 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10430-NF
    IGFBP-3 cDNA ORF Clone, Human, C-His tag HG10430-CH
    IGFBP-3 cDNA ORF Clone, Human, N-His tag HG10430-NH
    IGFBP-3 cDNA ORF Clone, Human, C-HA tag HG10430-CY
    IGFBP-3 cDNA ORF Clone, Human, N-HA tag HG10430-NY
    IGFBP-3 cDNA ORF Clone, Human, C-Myc tag HG10430-CM
    IGFBP-3 cDNA ORF Clone, Human, N-Myc tag HG10430-NM
    info info
    添加购物车成功! 添加购物车失败!