IDO2 qPCR Primer Pairs, Human

Cat: HP102299
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IDO2 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
IDO2 qPCR Primer Pairs, Human Alternative Names
INDOL1 qPCR Primer Pairs, Human
IDO2 Background Information

IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human tissues, its physiological role is not fully understood but is of great interest. IDO can be up-regulated via cytokines such as interferon-gamma, and can thereby modulate the levels of tryptophan, which is vital for cell growth. In humans and mice, the IDO1 and IDO2 genes are present tandemly in a tail-to-head arrangment on chromosome 8. In lower vertebrates such as zebrafish and toads only a single IDO gene may be present that may be more IDO2-like in structure. This closer relationship to IDO2 suggests that IDO2 may actually be the ancestor of the better characterized IDO1 gene, and that IDO1 might have been generated by gene duplication of IDO2 before the origin of tetrapods in mammalian evolutionary history. IDO2 catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

Full Name
indoleamine 2,3-dioxygenase 2
References
  • Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.
  • Sorensen RB, et al. (2011) Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Res. 71 (6): 2038-44.
  • Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.
  • IDO2 qPCR Primer Pairs, Mouse, Related Products

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    IDO2 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    IDO2 cDNA ORF Clone in Cloning Vector, Human HG13614-G
    IDO2 cDNA ORF Clone, Human, untagged HG13614-UT
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    IDO2 cDNA ORF Clone, Human, C-GFPSpark® tag HG13614-ACG
    IDO2 cDNA ORF Clone, Human, N-GFPSpark® tag HG13614-ANG
    IDO2 cDNA ORF Clone, Human, C-OFPSpark® tag HG13614-ACR
    IDO2 cDNA ORF Clone, Human, N-OFPSpark® tag HG13614-ANR
    IDO2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG13614-CF
    IDO2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG13614-NF
    IDO2 cDNA ORF Clone, Human, C-His tag HG13614-CH
    IDO2 cDNA ORF Clone, Human, N-His tag HG13614-NH
    IDO2 cDNA ORF Clone, Human, C-HA tag HG13614-CY
    IDO2 cDNA ORF Clone, Human, N-HA tag HG13614-NY
    IDO2 cDNA ORF Clone, Human, C-Myc tag HG13614-CM
    IDO2 cDNA ORF Clone, Human, N-Myc tag HG13614-NM
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