Hemojuvelin qPCR Primer Pairs, Human

Cat: HP100440
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Hemojuvelin qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
Hemojuvelin qPCR Primer Pairs, Human Alternative Names
HFE2A qPCR Primer Pairs, Human;HJV qPCR Primer Pairs, Human;JH qPCR Primer Pairs, Human;RGMC qPCR Primer Pairs, Human
Hemojuvelin Background Information

Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).

Full Name
hemochromatosis type 2 (juvenile)
References
  • Papanikolaou G, et al. (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 36(1):77-82.
  • Babitt JL, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 38(5):531-9.
  • Zhang AS, et al. (2008) Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem. 283(25):17494-502.
  • Hemojuvelin qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Rhesus CG90061-G
    Hemojuvelin cDNA ORF Clone, Rhesus, untagged CG90061-UT
    Hemojuvelin cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90061-ACG
    Hemojuvelin Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90061-ACGLN
    Hemojuvelin cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90061-ACR
    Hemojuvelin cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90061-CF
    Hemojuvelin cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90061-NF
    Hemojuvelin cDNA ORF Clone, Rhesus, C-His tag CG90061-CH
    Hemojuvelin cDNA ORF Clone, Rhesus, N-His tag CG90061-NH
    Hemojuvelin cDNA ORF Clone, Rhesus, C-HA tag CG90061-CY
    Hemojuvelin cDNA ORF Clone, Rhesus, N-HA tag CG90061-NY
    Hemojuvelin cDNA ORF Clone, Rhesus, C-Myc tag CG90061-CM
    Hemojuvelin cDNA ORF Clone, Rhesus, N-Myc tag CG90061-NM

    Hemojuvelin qPCR Primer Pairs, Rat, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Rat RG80142-G
    Hemojuvelin cDNA ORF Clone, Rat, untagged RG80142-UT
    Hemojuvelin Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80142-ACGLN
    Hemojuvelin cDNA ORF Clone, Rat, C-GFPSpark® tag RG80142-ACG
    Hemojuvelin cDNA ORF Clone, Rat, C-OFPSpark® tag RG80142-ACR
    Hemojuvelin cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80142-CF
    Hemojuvelin cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80142-NF
    Hemojuvelin cDNA ORF Clone, Rat, C-His tag RG80142-CH
    Hemojuvelin cDNA ORF Clone, Rat, N-His tag RG80142-NH
    Hemojuvelin cDNA ORF Clone, Rat, C-HA tag RG80142-CY
    Hemojuvelin cDNA ORF Clone, Rat, N-HA tag RG80142-NY
    Hemojuvelin cDNA ORF Clone, Rat, C-Myc tag RG80142-CM
    Hemojuvelin cDNA ORF Clone, Rat, N-Myc tag RG80142-NM

    Hemojuvelin qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Human HG10410-M
    Hemojuvelin cDNA ORF Clone, Human, untagged HG10410-UT
    Hemojuvelin cDNA ORF Clone, Human, C-GFPSpark® tag HG10410-ACG
    Hemojuvelin Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10410-ACGLN
    Hemojuvelin cDNA ORF Clone, Human, C-OFPSpark® tag HG10410-ACR
    Hemojuvelin cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10410-CF
    Hemojuvelin cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10410-NF
    Hemojuvelin cDNA ORF Clone, Human, C-His tag HG10410-CH
    Hemojuvelin cDNA ORF Clone, Human, N-His tag HG10410-NH
    Hemojuvelin cDNA ORF Clone, Human, C-HA tag HG10410-CY
    Hemojuvelin cDNA ORF Clone, Human, N-HA tag HG10410-NY
    Hemojuvelin cDNA ORF Clone, Human, C-Myc tag HG10410-CM
    Hemojuvelin cDNA ORF Clone, Human, N-Myc tag HG10410-NM
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