|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human GREM1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10632-ACG|
|Human GREM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10632-ACR|
|Human GREM1 ORF mammalian expression plasmid, C-Flag tag||HG10632-CF|
|Human GREM1 ORF mammalian expression plasmid, C-His tag||HG10632-CH|
|Human GREM1 ORF mammalian expression plasmid, C-Myc tag||HG10632-CM|
|Human GREM1 ORF mammalian expression plasmid, C-HA tag||HG10632-CY|
|Human GREM1 Gene cDNA clone plasmid||HG10632-G|
|Human GREM1 ORF mammalian expression plasmid, N-Flag tag||HG10632-NF|
|Human GREM1 ORF mammalian expression plasmid, N-His tag||HG10632-NH|
|Human GREM1 ORF mammalian expression plasmid, N-Myc tag||HG10632-NM|
|Human GREM1 ORF mammalian expression plasmid, N-HA tag||HG10632-NY|
|Human GREM1 natural ORF mammalian expression plasmid||HG10632-UT|
|Learn more about expression Vectors|
GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as inhibitor of monocyte chemotaxis. GREM1 is highly expressed in small intestine, fetal brain and colon.