GPNMB qPCR Primer Pairs, Human

Cat: HP101194
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GPNMB qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
GPNMB qPCR Primer Pairs, Human Alternative Names
HGFIN qPCR Primer Pairs, Human;NMB qPCR Primer Pairs, Human;Osteoactivin qPCR Primer Pairs, Human
GPNMB Background Information

GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.

Full Name
glycoprotein (transmembrane) nmb
References
  • Pahl MV. et al., 2010, Clin J Am Soc Nephrol. 5(1): 56-61.
  • Abdelmagid SM. et al., 2008, Exp Cell Res. 314(13): 2334-51.
  • Haralanova-Ilieva B. et al., 2005, J Hepatol. 242(4): 565-72.
  • Abdelmagid SM. et al., 2007, J Cell Physiol. 210(1): 26-37.
  • Furochi H. et al., 2007, J Med Invest. 54(3-4): 248-54.
  • GPNMB qPCR Primer Pairs, Mouse, Related Products

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    GPNMB qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    GPNMB cDNA ORF Clone in Cloning Vector, Human HG11305-M
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    GPNMB Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11305-ACGLN
    GPNMB cDNA ORF Clone, Human, C-OFPSpark® tag HG11305-ACR
    GPNMB cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11305-CF
    GPNMB cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11305-NF
    GPNMB cDNA ORF Clone, Human, C-His tag HG11305-CH
    GPNMB cDNA ORF Clone, Human, N-His tag HG11305-NH
    GPNMB cDNA ORF Clone, Human, C-HA tag HG11305-CY
    GPNMB cDNA ORF Clone, Human, N-HA tag HG11305-NY
    GPNMB cDNA ORF Clone, Human, C-Myc tag HG11305-CM
    GPNMB cDNA ORF Clone, Human, N-Myc tag HG11305-NM
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