ENPP2 qPCR Primer Pairs, Human

Cat: HP101196
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ENPP2 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
ENPP2 qPCR Primer Pairs, Human Alternative Names
ATX qPCR Primer Pairs, Human;ATX-X qPCR Primer Pairs, Human;AUTOTAXIN qPCR Primer Pairs, Human;LysoPLD qPCR Primer Pairs, Human;NPP2 qPCR Primer Pairs, Human;PD-IALPHA qPCR Primer Pairs, Human;PDNP2 qPCR Primer Pairs, Human
ENPP2 Background Information

ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.

Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
References
  • Tania M, et al. (2010) Autotaxin: a protein with two faces. Biochem Biophys Res Commun. 401(4): 493-7.
  • Ikeda H, et al. (2009) Significance of serum autotaxin activity in gastrointestinal disease. Rinsho Byori. 57(5): 445-9.
  • Parrill AL, et al. (2008) Autotaxin inhibition: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med Chem. 8(8): 917-23.
  • Pradere J.P, et al. (2007) Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase. Biochim Biophys Acta. 1771: 93-102.
  • Boucher J, et al. (2005) Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia. 48: 569-77.
  • ENPP2 qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    ENPP2 cDNA ORF Clone in Cloning Vector, Rhesus CG90223-G
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    ENPP2 qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    ENPP2 cDNA ORF Clone in Cloning Vector, Mouse MG50663-G
    ENPP2 cDNA ORF Clone, Mouse, untagged MG50663-UT
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    ENPP2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50663-ACGLN
    ENPP2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50663-ACR
    ENPP2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50663-CF
    ENPP2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50663-NF
    ENPP2 cDNA ORF Clone, Mouse, C-His tag MG50663-CH
    ENPP2 cDNA ORF Clone, Mouse, N-His tag MG50663-NH
    ENPP2 cDNA ORF Clone, Mouse, C-HA tag MG50663-CY
    ENPP2 cDNA ORF Clone, Mouse, N-HA tag MG50663-NY
    ENPP2 cDNA ORF Clone, Mouse, C-Myc tag MG50663-CM
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    ENPP2 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    ENPP2 cDNA ORF Clone in Cloning Vector, Human HG11308-M
    ENPP2 cDNA ORF Clone, Human, untagged HG11308-UT
    ENPP2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11308-ACGLN
    ENPP2 cDNA ORF Clone, Human, C-GFPSpark® tag HG11308-ACG
    ENPP2 cDNA ORF Clone, Human, C-OFPSpark® tag HG11308-ACR
    ENPP2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11308-CF
    ENPP2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11308-NF
    ENPP2 cDNA ORF Clone, Human, C-His tag HG11308-CH
    ENPP2 cDNA ORF Clone, Human, N-His tag HG11308-NH
    ENPP2 cDNA ORF Clone, Human, C-HA tag HG11308-CY
    ENPP2 cDNA ORF Clone, Human, N-HA tag HG11308-NY
    ENPP2 cDNA ORF Clone, Human, C-Myc tag HG11308-CM
    ENPP2 cDNA ORF Clone, Human, N-Myc tag HG11308-NM
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