Endothelin A Receptor cDNA ORF Clone, Human, N-Myc tag

Cat: HG14459-NM
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Endothelin A Receptor cDNA ORF Clone, Human, N-Myc tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1284 bp
Description
Full length Clone DNA of Human endothelin receptor type A with N terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-SP-N-Myc
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Endothelin A Receptor cDNA ORF Clone, Human, N-Myc tag Alternative Names
ET-A cDNA ORF Clone, Human;ETA cDNA ORF Clone, Human;ETA-R cDNA ORF Clone, Human;ETAR cDNA ORF Clone, Human;ETRA cDNA ORF Clone, Human;hET-AR cDNA ORF Clone, Human
Endothelin A Receptor Background Information

The product of EDNRA, endothelin receptor A, is a G protein-coupled receptor that causes cellular proliferation and contraction (26, 27) of smooth muscle when ligated to endothelin. Polymorphisms in this gene have been associated with variation in vascular phenotypes stemming from vasoconstriction.This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
endothelin receptor type A
References
  • Darrah R, McKone E, O'Connor C, et al. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity[J]. Physiological genomics, 2010, 41(1): 71-77.
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