Cathepsin S qPCR Primer Pairs, Human

Cat: HP100509
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Cathepsin S qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
Cathepsin S qPCR Primer Pairs, Human Alternative Names
CTSS qPCR Primer Pairs, Human;MGC3886 qPCR Primer Pairs, Human
Cathepsin S Background Information

Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Compared with other lysosomal cysteine proteases, cathepsin S has displayed some unique characteristics. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, although direct evidence is still lacking, in its secreted form cathepsin S is implicated in degradation of the extracellular matrix, which may contribute to the pathology of a number of diseases, including arthritis, atherosclerosis, neurological diseases and chronic obstructive pulmonary disease.

Full Name
cathepsin S
References
  • Liu W, et al. (2004) Cysteine protease cathepsin S as a key step in antigen presentation. Drug News Perspect. 17(6): 357-63.
  • Thurmond RL, et al. (2005) Cathepsin S inhibitors as novel immunomodulators. Curr Opin Investig Drugs. 6(5): 473-82.
  • Wang DM, et al. (2008) Cathepsin S in pathogenesis of neurological diseases. Zhejiang Da Xue Xue Bao Yi Xue Ban. 37(4): 422-6.
  • Cathepsin S qPCR Primer Pairs, Rat, Related Products

    Product Name Catalog#(PDF)
    Cathepsin S cDNA ORF Clone in Cloning Vector, Rat RG80443-G
    Cathepsin S cDNA ORF Clone, Rat, untagged RG80443-UT
    Cathepsin S cDNA ORF Clone, Rat, C-GFPSpark® tag RG80443-ACG
    Cathepsin S Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80443-ACGLN
    Cathepsin S cDNA ORF Clone, Rat, C-OFPSpark® tag RG80443-ACR
    Cathepsin S cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80443-CF
    Cathepsin S cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80443-NF
    Cathepsin S cDNA ORF Clone, Rat, C-His tag RG80443-CH
    Cathepsin S cDNA ORF Clone, Rat, N-His tag RG80443-NH
    Cathepsin S cDNA ORF Clone, Rat, C-HA tag RG80443-CY
    Cathepsin S cDNA ORF Clone, Rat, N-HA tag RG80443-NY
    Cathepsin S cDNA ORF Clone, Rat, C-Myc tag RG80443-CM
    Cathepsin S cDNA ORF Clone, Rat, N-Myc tag RG80443-NM

    Cathepsin S qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    Cathepsin S cDNA ORF Clone in Cloning Vector, Mouse MG51402-G
    Cathepsin S cDNA ORF Clone in Cloning Vector, Mouse MG50769-G
    Cathepsin S cDNA ORF Clone, Mouse, untagged MG50769-UT
    Cathepsin S cDNA ORF Clone, Mouse, untagged MG51402-UT
    Cathepsin S Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50769-ACGLN
    Cathepsin S cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51402-ACG
    Cathepsin S cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50769-ACG
    Cathepsin S Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51402-ACGLN
    Cathepsin S cDNA ORF Clone, Mouse, C-OFPSpark® tag MG51402-ACR
    Cathepsin S cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50769-ACR
    Cathepsin S cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50769-CF
    Cathepsin S cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG51402-CF
    Cathepsin S cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG51402-NF
    Cathepsin S cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50769-NF
    Cathepsin S cDNA ORF Clone, Mouse, C-His tag MG51402-CH
    Cathepsin S cDNA ORF Clone, Mouse, C-His tag MG50769-CH
    Cathepsin S cDNA ORF Clone, Mouse, N-His tag MG50769-NH
    Cathepsin S cDNA ORF Clone, Mouse, N-His tag MG51402-NH
    Cathepsin S cDNA ORF Clone, Mouse, C-HA tag MG50769-CY
    Cathepsin S cDNA ORF Clone, Mouse, C-HA tag MG51402-CY
    Cathepsin S cDNA ORF Clone, Mouse, N-HA tag MG51402-NY
    Cathepsin S cDNA ORF Clone, Mouse, N-HA tag MG50769-NY
    Cathepsin S cDNA ORF Clone, Mouse, C-Myc tag MG51402-CM
    Cathepsin S cDNA ORF Clone, Mouse, C-Myc tag MG50769-CM
    Cathepsin S cDNA ORF Clone, Mouse, N-Myc tag MG51402-NM
    Cathepsin S cDNA ORF Clone, Mouse, N-Myc tag MG50769-NM

    Cathepsin S qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    Cathepsin S cDNA ORF Clone in Cloning Vector, Human HG10487-U
    Cathepsin S cDNA ORF Clone, Human, untagged HG10487-UT
    Cathepsin S cDNA ORF Clone, Human, C-GFPSpark® tag HG10487-ACG
    Cathepsin S Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10487-ACGLN
    Cathepsin S cDNA ORF Clone, Human, C-OFPSpark® tag HG10487-ACR
    Cathepsin S cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10487-CF
    Cathepsin S cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10487-NF
    Cathepsin S cDNA ORF Clone, Human, C-His tag HG10487-CH
    Cathepsin S cDNA ORF Clone, Human, N-His tag HG10487-NH
    Cathepsin S cDNA ORF Clone, Human, C-HA tag HG10487-CY
    Cathepsin S cDNA ORF Clone, Human, N-HA tag HG10487-NY
    Cathepsin S cDNA ORF Clone, Human, C-Myc tag HG10487-CM
    Cathepsin S cDNA ORF Clone, Human, N-Myc tag HG10487-NM
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