NY-ESO-1 cDNA ORF Clone, Human, C-Myc tag

Cat: HG15611-CM
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NY-ESO-1 cDNA ORF Clone, Human, C-Myc tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
543 bp
Description
Full length Clone DNA of Human cancer/testis antigen 1A with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

NY-ESO-1 cDNA ORF Clone, Human, C-Myc tag Alternative Names
CT6.1 cDNA ORF Clone, Human;ESO1 cDNA ORF Clone, Human;LAGE-2 cDNA ORF Clone, Human;LAGE2A cDNA ORF Clone, Human;NY-ESO-1 cDNA ORF Clone, Human
NY-ESO-1 Background Information

NY-ESO-1 is another well-characterized CT antigen that appears to be the most immunogenic CT antigen known to date. Integrated humoral and cellular immune response against NY-ESO-1 are frequently observed in patients with tumors with NY-ESO-1 expression. As a member of CT antigens, NY-ESO-1 is expressed in a variety of malignant neoplasms, including melanomas, and esophageal, breast, prostate, urinary tract, ovarian, and lung cancers. Recently, immunohistochemical and molecular analytical approaches for the detection of NY-ESO-1 expression were compared, defining the reliability of each method. However, its clinical significance, e.g. in prognosis, in lung cancer is unclear.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
cancer/testis antigen 1A
References
  • Yoshida N, Abe H, Ohkuri T, et al. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance[J]. International journal of oncology, 2006, 28(5): 1089-1098.
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