Clusterin cDNA ORF Clone, Human, C-Myc tag

Cat: HG11297-CM
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Clusterin cDNA ORF Clone, Human, C-Myc tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1506 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 6 G/A, 945 T/C not causing the amino acid variation.
Description
Full length Clone DNA of Human clusterin with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-Myc
Restriction Sites
KpnI + XbaI (6kb + 1.55kb)
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
Clusterin cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Clusterin cDNA ORF Clone, Human, C-Myc tag Validated Images
other Green fluorescent protein / GFP Gene Plasmid Map 5611
Clusterin cDNA ORF Clone, Human, C-Myc tag Alternative Names
AAG4 cDNA ORF Clone, Human;APO-J cDNA ORF Clone, Human;APOJ cDNA ORF Clone, Human;CLI cDNA ORF Clone, Human;CLU1 cDNA ORF Clone, Human;CLU2 cDNA ORF Clone, Human;KUB1 cDNA ORF Clone, Human;NA1/NA2 cDNA ORF Clone, Human;SGP-2 cDNA ORF Clone, Human;SGP2 cDNA ORF Clone, Human;SP-40 cDNA ORF Clone, Human;TRPM-2 cDNA ORF Clone, Human;TRPM2 cDNA ORF Clone, Human
Clusterin Background Information

Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Full Name
clusterin
References
  • Silkensen JR, et al. (1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12): 483-8.
  • Naik RR, et al. (2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72.
  • Djeu JY, et al. (2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.
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    Clusterin cDNA ORF Clone, Canine, Related Products

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    Clusterin cDNA ORF Clone, Canine, C-His tag DG70207-CH
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    Clusterin cDNA ORF Clone, Rat, Related Products

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    Product Name Catalog#(PDF)
    Clusterin cDNA ORF Clone in Cloning Vector, Human HG11297-M
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    Clusterin cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11297-CF
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