CLIC4 qPCR Primer Pairs, Human

Cat: HP101882
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CLIC4 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
CLIC4 qPCR Primer Pairs, Human Alternative Names
CLIC4L qPCR Primer Pairs, Human;H1 qPCR Primer Pairs, Human;huH1 qPCR Primer Pairs, Human;MTCLIC qPCR Primer Pairs, Human;p64H1 qPCR Primer Pairs, Human
CLIC4 Background Information

Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains one GST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.

Full Name
chloride intracellular channel 4
References
  • Ronnov-Jessen L., et al., 2002, Am. J. Pathol. 161:471-480.
  • Berryman M.A., et al., 2003, Cell Motil. Cytoskeleton 56:159-172.
  • Suh,K.S. et al., 2005, J Investig Dermatol Symp Proc. 10 (2):105-9.
  • Suh,K.S. et al., 2007, Mol Carcinog.46 (8):599-604.
  • Suh,K.S. et al., 2007, J Cell Sci  120 (Pt 15):2631-40.
  • Suh,K.S. et al., 2007, Clin Cancer Res  13 (1):121-31.
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    CLIC4 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
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    CLIC4 cDNA ORF Clone, Human, C-GFPSpark® tag HG12271-ACG
    CLIC4 cDNA ORF Clone, Human, N-GFPSpark® tag HG12271-ANG
    CLIC4 cDNA ORF Clone, Human, C-OFPSpark® tag HG12271-ACR
    CLIC4 cDNA ORF Clone, Human, N-OFPSpark® tag HG12271-ANR
    CLIC4 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG12271-CF
    CLIC4 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG12271-NF
    CLIC4 cDNA ORF Clone, Human, C-His tag HG12271-CH
    CLIC4 cDNA ORF Clone, Human, N-His tag HG12271-NH
    CLIC4 cDNA ORF Clone, Human, C-HA tag HG12271-CY
    CLIC4 cDNA ORF Clone, Human, N-HA tag HG12271-NY
    CLIC4 cDNA ORF Clone, Human, C-Myc tag HG12271-CM
    CLIC4 cDNA ORF Clone, Human, N-Myc tag HG12271-NM
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