CES2 cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG10380-M-F
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CES2 cDNA ORF Clone, Human, C-DDK (Flag®) tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1872 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human carboxylesterase 2 (intestine, liver) with Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV2-FLAG
Restriction Sites
KpnI + XbaI (5.4kb + 1.92kb)
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
CES2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CES2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Validated Images
Human FANCG/FAG Gene Plasmid Map 7220
CES2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names
CE-2 cDNA ORF Clone, Human;CES2A1 cDNA ORF Clone, Human;iCE cDNA ORF Clone, Human;PCE-2 cDNA ORF Clone, Human
CES2 Background Information

Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

Full Name
carboxylesterase 2
References
  • Imai T. et al. (2006) Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug metab pharmacokinet. 21 (3): 173-85.
  • Guang Xu, et al. (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res. 8: 2605.
  • Zhang, et al. (2002) Comprehensive Evaluation of Carboxylesterase-2 Expression in Normal Human Tissues Using Tissue Array Analysis. Applied Immunohistochemistry & Molecular Morphology. 10 (4): 374-80.
  • CES2 cDNA ORF Clone, Mouse, Related Products

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    CES2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CES2 cDNA ORF Clone in Cloning Vector, Human HG10380-M
    CES2 cDNA ORF Clone, Human, untagged HG10380-UT
    CES2 cDNA ORF Clone, Human, C-GFPSpark® tag HG10380-ACG
    CES2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10380-ACGLN
    CES2 cDNA ORF Clone, Human, N-GFPSpark® tag HG10380-ANG
    CES2 cDNA ORF Clone, Human, C-OFPSpark® tag HG10380-ACR
    CES2 cDNA ORF Clone, Human, N-OFPSpark® tag HG10380-ANR
    CES2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10380-CF
    CES2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10380-NF
    CES2 cDNA ORF Clone, Human, C-His tag HG10380-CH
    CES2 cDNA ORF Clone, Human, N-His tag HG10380-NH
    CES2 cDNA ORF Clone, Human, C-HA tag HG10380-CY
    CES2 cDNA ORF Clone, Human, N-HA tag HG10380-NY
    CES2 cDNA ORF Clone, Human, C-Myc tag HG10380-CM
    CES2 cDNA ORF Clone, Human, N-Myc tag HG10380-NM
    CES2 qPCR Primer Pairs, Human HP105189
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