CD33 qPCR Primer Pairs, Human

Cat: HP103201
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CD33 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
CD33 qPCR Primer Pairs, Human Alternative Names
p67 qPCR Primer Pairs, Human;Siglec-3 qPCR Primer Pairs, Human;SIGLEC3 qPCR Primer Pairs, Human
CD33 Background Information

Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD33 molecule
References
  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.
  • CD33 qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    CD33 cDNA ORF Clone in Cloning Vector, Rhesus CG90183-G
    CD33 cDNA ORF Clone, Rhesus, untagged CG90183-UT
    CD33 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90183-ACGLN
    CD33 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90183-ACG
    CD33 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90183-ACR
    CD33 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90183-CF
    CD33 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90183-NF
    CD33 cDNA ORF Clone, Rhesus, C-His tag CG90183-CH
    CD33 cDNA ORF Clone, Rhesus, N-His tag CG90183-NH
    CD33 cDNA ORF Clone, Rhesus, C-HA tag CG90183-CY
    CD33 cDNA ORF Clone, Rhesus, N-HA tag CG90183-NY
    CD33 cDNA ORF Clone, Rhesus, C-Myc tag CG90183-CM
    CD33 cDNA ORF Clone, Rhesus, N-Myc tag CG90183-NM

    CD33 qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    CD33 cDNA ORF Clone in Cloning Vector, Mouse MG50712-G
    CD33 cDNA ORF Clone, Mouse, untagged MG50712-UT
    CD33 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50712-ACGLN
    CD33 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50712-ACG
    CD33 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50712-ACR
    CD33 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50712-CF
    CD33 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50712-NF
    CD33 cDNA ORF Clone, Mouse, C-His tag MG50712-CH
    CD33 cDNA ORF Clone, Mouse, N-His tag MG50712-NH
    CD33 cDNA ORF Clone, Mouse, C-HA tag MG50712-CY
    CD33 cDNA ORF Clone, Mouse, N-HA tag MG50712-NY
    CD33 cDNA ORF Clone, Mouse, C-Myc tag MG50712-CM
    CD33 cDNA ORF Clone, Mouse, N-Myc tag MG50712-NM

    CD33 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    CD33 cDNA ORF Clone in Cloning Vector, Human HG12238-G
    CD33 cDNA ORF Clone, Human, untagged HG12238-UT
    CD33 cDNA ORF Clone, Human, C-GFPSpark® tag HG12238-ACG
    CD33 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG12238-ACGLN
    CD33 cDNA ORF Clone, Human, C-OFPSpark® tag HG12238-ACR
    CD33 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG12238-CF
    CD33 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG12238-NF
    CD33 cDNA ORF Clone, Human, C-His tag HG12238-CH
    CD33 cDNA ORF Clone, Human, N-His tag HG12238-NH
    CD33 cDNA ORF Clone, Human, C-HA tag HG12238-CY
    CD33 cDNA ORF Clone, Human, N-HA tag HG12238-NY
    CD33 cDNA ORF Clone, Human, C-Myc tag HG12238-CM
    CD33 cDNA ORF Clone, Human, N-Myc tag HG12238-NM
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