ANGPTL4 cDNA ORF Clone, Human, C-His tag

Cat: HG10563-CH
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ANGPTL4 cDNA ORF Clone, Human, C-His tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1266 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human angiopoietin-like 4, transcript variant 1 with C terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-His
Restriction Sites
KpnI + XbaI(6kb+1.27kb)
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
ANGPTL4 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ANGPTL4 cDNA ORF Clone, Human, C-His tag Validated Images
other Green fluorescent protein / GFP Gene Plasmid Map 5610
ANGPTL4 cDNA ORF Clone, Human, C-His tag Alternative Names
ANGPTL2 cDNA ORF Clone, Human;ARP4 cDNA ORF Clone, Human;FIAF cDNA ORF Clone, Human;HARP cDNA ORF Clone, Human;HFARP cDNA ORF Clone, Human;NL2 cDNA ORF Clone, Human;PGAR cDNA ORF Clone, Human;pp1158 cDNA ORF Clone, Human;TGQTL cDNA ORF Clone, Human;UNQ171 cDNA ORF Clone, Human
ANGPTL4 Background Information

ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Full Name
angiopoietin-like 4
References
  • Lichtenstein L, et al. (2010) Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages. Cell metabolism. 12(6): 580-92.
  • Terada S, et al. (2011) Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1. Cancer Cell. 19(3):297-9.
  • Zhu PC, et al. (2011) Angptl4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell. 19(3):401-15.
  • ANGPTL4 cDNA ORF Clone, Cynomolgus, Related Products

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    ANGPTL4 cDNA ORF Clone in Cloning Vector, Cynomolgus CG90529-U
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    ANGPTL4 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    ANGPTL4 cDNA ORF Clone in Cloning Vector, Mouse MG50356-M
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    ANGPTL4 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    ANGPTL4 cDNA ORF Clone in Cloning Vector, Human HG10563-M
    ANGPTL4 cDNA ORF Clone, Human, untagged HG10563-UT
    ANGPTL4 cDNA ORF Clone, Human, C-GFPSpark® tag HG10563-ACG
    ANGPTL4 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10563-ACGLN
    ANGPTL4 cDNA ORF Clone, Human, C-OFPSpark® tag HG10563-ACR
    ANGPTL4 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10563-CF
    ANGPTL4 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10563-NF
    ANGPTL4 cDNA ORF Clone, Human, N-His tag HG10563-NH
    ANGPTL4 cDNA ORF Clone, Human, C-HA tag HG10563-CY
    ANGPTL4 cDNA ORF Clone, Human, N-HA tag HG10563-NY
    ANGPTL4 cDNA ORF Clone, Human, C-Myc tag HG10563-CM
    ANGPTL4 cDNA ORF Clone, Human, N-Myc tag HG10563-NM
    ANGPTL4 qPCR Primer Pairs, Human HP100574
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