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Human ADORA3 qPCR primer pairs

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    Human ADORA3 qPCR Product Information
    NCBI RefSeq:
    Gene Synonym:A3AR, AD026, bA552M11.5, RP11-552M11.7
    PCR_SIZE (bp):
    QPCR Primer Description:Verified forward and reverse primers for analyzing the quantitative expression of gene
    Quality Control:The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480
    Shipping_carrier:1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions) is shipped at ambiente temperatura.
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    Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.

    Unique Primer Design

    To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.

    Strict Validation Process

    Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.

    Uniform PCR conditions, Saving time and cost

    ~100% amplification curve, ensuring the accuracy of the RNA quantitative

    Adenosine A3 Receptor/ADORA3 Background

    Adenosine A3 receptor (A3AR) is a Gi-protein-coupled receptor that, when being activated, decreases intracellular cAMP levels. The A3AR gene contains 2 exons that are separated by a single intron of approximately 2.2 kb, located on human chromosome 1p21-p13. There is extensive evidence for the involvement of A3AR in a number of pathophysiological processes including ischemic conditions of the central nervous system and heart and inflammatory states, such as rheumatoid arthritis (RA), Crohn's disease, and tumors. Therefore, A3AR is an important target for a number of inflammatory, neoplastic, and neurodegenerative conditions.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Human Adenosine A3 Receptor/ADORA3 References
  • Ren T, Qiu Y, Wu W, et al. Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells. Mediators of Inflammation. 2014;2014:818251.
  • Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology. 2014;171(16):3827-3844.
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.