Hemopexin

Hemopexin binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Hemopexin Related Areas

Cardiovascular>>Red Blood Cell>>Hemopexin/HPX

Immunology>>Innate Immunity>>Acute Phase Proteins>>Hemopexin/HPX

Hemopexin Alternative Names

Hemopexin, HPX, HX, FLJ56652 [Homo sapiens]

Hemopexin, Hpx, Hpxn, hx [Mus musculus]

Summaries for Hemopexin

Entrez Gene summary for HPX:

This HPX gene encodes a plasma glycoprotein that binds heme with high affinity. Hemopexin is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

OMIM - description for Hemopexin:

Hemopexin is a plasma beta-glycoprotein that specifically binds one heme with high affinity and transports it to hepatocytes for salvage of iron (summary by Takahashi et al., 1985).

Wikipedia summary for Hemopexin:

Hemopexin (or haemopexin; HPX), also known as beta-1B-glycoprotein is a protein that in humans is encoded by the HPX gene and belongs to hemopexin family of proteins.

Human Hemopexin Protein General Information

 

• Protein names: Hemopexin
• Sequence length: 462 AA.
• Sequence similarities: Hemopexin belongs to the hemopexin family. Hemopexin contains 5 hemopexin-like domains.
• Post-translational modification: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
• Subunit structure: Hemopexin interacts with HEV ORF3 protein. Hemopexin interacts with FLVCR1.
• Subcellular location: Secreted.
• Tissue specificity: Hemopexin is expressed by the liver and secreted in plasma.
• Miscellaneous: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear

General information above from UniProt

Function for Hemopexin Protein

UniProtKB:

Hemopexin binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Genatlas:

• Hemopexin transports heme to hepatocytes for iron salvage
• Hemopexin binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

Homology for human Hemopexin

• ortholog to rattus Hpx
• ortholog to murine Hpxn