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> Hematopoietic Stem Cell Markers Hematopoietic Stem Cell Markers
| Protein Name | Alternative Names | BioChemical Class / Role | Products (Cat NO) |
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| Protein | Antibody | Gene cDNA clones | |||
| CD34 | A single-pass transmembrane sialomucin protein, selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. CD34 has been widely used as a stem and progenitor cell marker, and CD34 monoclonal antibodies are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias. | 10103-H02H 10103-H08H |
HG10103-M | ||
| CD38 | T10 | A glycoprotein found on the surface of many immune cells, including CD4+, CD8+, B and natural killer cells, which functions in cell adhesion, signal transduction and calcium signaling. CD38 has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions. | 10818-H08H 50191-M08H |
10818-MM03 10818-MM04 10818-RP01 10818-RP02 |
HG10818-M MG50191-M |
| CD48 | SLAMF2, BCM1 | A GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules, receptor for CD4 and 2B4. CD48 functions in a variety processes including adhesion, pathogen recognition, cellular activation, as well as cytokine regulation, and emerges as a critical effector molecule in immune responses. | HG10797-M | 10797-H08H | 10797-MM02 10797-MM03 10797-RP01 10797-RP04 |
| CD150 | SLAM, SLAMF1 | Signaling lymphocytic activation molecule family member 1, expressed on thymocytes, memory T cells, B cells, platelets, natural killer T (NKT) cells, and mature dendritic cells. CD150 serves as a measles virus receptor and is involved in the regulation of differentiation and/or function of T helper (TH) 1 and TH2 cells, B lymphocytes, innate-like lymphocytes, dendritic cells and macrophages. | 10837-H08H | 10837-RP01 10837-RP02 |
HG10837-M |
| Endoglin | CD105 | A membrane glycoprotein receptor for several TGF-beta superfamily members. It has a role in the development of the cardiovascular system and in vascular remodeling. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1. | 10149-H02H | HG10149-M | |
| Flt3 | CD135, Flk2 | A cytokine receptor expressed on the surface of hematopoietic progenitor cells, used as a cell surface marker to identify certain types of hematopoietic progenitors. CD35 binds to Flt3L and stimulates signaling related to cell survival, proliferation, and differentiation. Mutations of this protein can lead to cancer. | 10445-H08H | HG10445-M | |
| Mcl-1 | HG10240-M | ||||
| PTEN | BZS, MHAM, TEP1, MMAC1, PTEN1, 10q23del, MGC11227 | Phosphatase and tensin homolog. PTEN acts as a tumor suppressor gene, and is mutated in a large number of cancers at high frequency. The PTEN protein is a phosphatase that is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. | HG10421-M | ||
| STAT5a | HG10035-M | ||||
| VEGFR2 | KDR, CD309, Flk1 | A vascular endothelial growth factor (VEGF) receptor. | 10012-H02H | HG10012-M | |
