Hemangioblast Markers

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
CD31	PECAM-1	A transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets that plays a key role in removing aged neutrophils,  tissue regeneration, neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies.	10148-H02H 10148-H08H 10148-HCCH	10148-MM01 10148-MM02	HG10148-M
CD34		A single-pass transmembrane sialomucin protein, selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. CD34 has been widely used as a stem and progenitor cell marker, and CD34 monoclonal antibodies are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias.	10103-H02H 10103-H08H		HG10103-M
E-Cadherin	CDH1, CD324	A classical cadherin from the cadherin superfamily with calcium-dependent activity. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis.	10204-H08H		HG10204-M
Endoglin	CD105	A membrane glycoprotein receptor for several TGF-beta superfamily members. It has a role in the development of the cardiovascular system and in vascular remodeling. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1.	10149-H02H		HG10149-M
EphB4		A single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. EphB4 protein has tumor suppressor activities and plays a role in  regulation of cell proliferation, extracellular matrix remodeling, and invasive potential.	10235-H02H 10235-H08H 10235-HCCH	10235-MM03 10235-MM04 10235-RM02 10235-RP01 10235-RP05	HG10235-M
Tie2	TEK, CD202b	A Tyrosine Kinase receptor for the angiopoietins (Ang1, Ang2, Ang3, Ang4).	10700-H03H 10700-H08H		HG10700-M
VE-Cadherin	CD144, CDH5	A classical cadherin from the cadherin superfamily with calcium-dependent activity. VE-Cadherin is required for maintaining a restrictive endothelial barrier and indispensable for proper vascular development. It also has a role in maintaining newly formed vessels.	50192-M08H		HG10433-M MG50192-M
VEGFR2	KDR, CD309, Flk1	A vascular endothelial growth factor (VEGF) receptor.	10012-H02H		HG10012-M