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> Hemangioblast Marker Hemangioblast Marker
Sino Biological provides a comprehensive set of tools for hemangioblast marker related studies, including recombinant proteins, antibodies (rabbit MAb & PAb, mouse MAb), ELISA kits, and ORF cDNA clones.
Hemangioblast Marker Products
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Hemangioblast Background
Hemangioblasts are multipotent cells that are derived from the mesoderm and have the capacity of differentiate into hematopoietic and endothelial cells. The hemangioblast hypothesis was proposed a century ago. The existence of hemangioblasts is now demonstrated in mouse and human embryonic stem cell (ES cell)-derived embryoid bodies (EBs). The existence of hemangioblasts was first suggested by morphological studies of yolk sac development, specifically the close developmental association of hematopoietic and endothelial lineages within the blood islands. Hemangioblasts cannot be identified morphologically but they share some features with hematopoietic stem cells, including expression of CD34, flk-1 and various transcription factors such as LMO2, SCL (Tal-1), GATA-2, some of which are required for primitive hematopoiesis and others for definite hematopoiesis. Recent study by He WY et al. indicates a role of IL-3 in hemangioblast development in that both hematopoietic and endothelial differentiation potential were significantly increased in IL-3-treated BL-CFC.
Hemangioblast Related Studies
- Loges S, et al. (2004). Identification of the Adult Hemangioblast. Stem Cells and Development 13 (1):229-42.
- Marion Kennedy, et al. (2007) Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 107: 2679-87.
- Xiong JW. (2008) Molecular and developmental biology of the hemangioblast. Dev Dyn. 237(5):1218-31.
- Pimanda JE, et al. (2008) Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code. Blood. 112(12):4512-22.
- Lancrin C, et al. (2010) Blood cell generation from the hemangioblast. J Mol Med. 88(2):167-72.
