HVEM (Protein|Antibody|cDNA Clone|ELISA Kit)

All HVEM reagents are produced in house and quality controlled, including 11 HVEM Antibody, 49 HVEM Gene, 6 HVEM Lysate, 6 HVEM Protein, 3 HVEM qPCR. All HVEM reagents are ready to use.

Recombinant HVEM proteins are expressed by HEK293 Cells, CHO Stable Cells with fusion tags as C-His, C-human IgG1-Fc, C-human IgG1-Fc & His, C-His & C-human IgG1-Fc.

HVEMantibodies are validated with different applications, which are FCM, ELISA.

HVEMcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each HVEM of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

HVEM Protein (6)

Species

HVEM Protein, Mouse, Recombinant (His & Fc Tag)

10567-M03S

Expression host: CHO Stable Cells

Mouse HVEM/TNFRSF14/CD270 Protein 8935

HVEM Protein, Human, Recombinant (His Tag)

10334-H08H

Expression host: HEK293 Cells

Human HVEM/TNFRSF14/CD270 Protein 8680

HVEM Protein, Mouse, Recombinant (His & Fc Tag)

10567-M03H

Expression host: HEK293 Cells

Mouse HVEM/TNFRSF14/CD270 Protein 8934

HVEM Protein, Cynomolgus, Recombinant (Fc Tag)

90109-C02H

Expression host: HEK293 Cells

Cynomolgus HVEM/TNFRSF14/CD270 Protein 12809

HVEM Protein, Human, Recombinant (His & Fc Tag)

10334-H03H

Expression host: HEK293 Cells

Human HVEM/TNFRSF14/CD270 Protein 8679

HVEM Protein, Human, Recombinant, Biotinylated

10334-H03H-B

Expression host: HEK293 Cells

Human HVEM/TNFRSF14/CD270 Protein 18564
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HVEM Antibody (11)

Application Clonality
Host

Anti-HVEM Antibody (APC)

10334-MM11-A

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15951

Anti-HVEM Antibody (FITC)

10334-R004-F

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15370

Anti-HVEM Antibody

10334-R028

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-HVEM Antibody (PE)

10334-MM11-P

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15369

Anti-HVEM Antibody

10334-MM13

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-HVEM Antibody

10334-R004

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15376

Anti-HVEM Antibody (PE)

10334-R004-P

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15371

Anti-HVEM Antibody

10334-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-HVEM Antibody

10334-MM11

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 15379

Anti-HVEM Antibody (APC)

10334-R004-A

Specificity: Human

Application: FCM

Clonality: MAb

Human HVEM/TNFRSF14/CD270 Flow Cytometry (FC) 17165

Anti-HVEM Antibody

10334-T16

Specificity: Human

Application: ELISA

Clonality: PAb

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HVEM cDNA Clone (49)

Human
Rat
Rhesus
Mouse

HVEM qPCR Primer (3)

HVEM Lysate (6)

Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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