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HSPD1/HSP60 Rabbit PAb , Antigen Affinity Purified

  • HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified
  • HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Mouse HSPD1 Antibody Product Information
Immunogen:Recombinant Mouse HSPD1 / HSP60 protein (Catalog#50596-M07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse HSPD1 / HSP60 (rM HSPD1 / HSP60; Catalog#50596-M07E; NP_034607.3; Leu 2-Phe 573). HSPD1 / HSP60 specific IgG was purified by Mouse HSPD1 / HSP60 affinity chromatography.
Mouse HSPD1 Antibody WB Application Image
Mouse HSPD1 Antibody IHC Application Image
HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse HSP60 in mouse intestine with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse HSP60 in mouse kidney with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule.
HSPD1 / HSP60 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse HSP60 in mouse lung with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Mouse HSPD1 Antibody IP Application Image
Other HSPD1 Antibody Products
HSPD1/HSP60 Background

HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.

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Mouse HSPD1/HSP60 References
  • Hansen J J, et al. (2002) Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60. Am J Hum Genet. 70: 1328-32.
  • Magen D, et al. (2008) Mitochondrial Hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. Am J Hum Genet. 83: 30-42.
  • Venner TJ, et al. (1990) Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families. DNA Cell Biol. 9 (8): 545-52.
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    Catalog: 50596-RP02-50
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    Datasheet & Documentation

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"