HSPA8 / HSC70 Protein

Heat shock 70kDa protein 8

HSPA8 / HSC70 Products

HSPA8 / HSC70 Protein, Recombinant

Molecule	Species	Description	Cat. No
HSPA8/HSC70	Human	HSPA8/HSC70 Protein, Recombinant	11329-H07E

HSPA8 / HSC70 cDNA Clone

Molecule	Species	Description	Cat. No
HSPA8/HSC70	Human	Human HSPA8/HSC70 cDNA Clone / ORF Clone	HG11329-M

HSPA8 / HSC70 Related Areas

Cancer>>Apoptosis>>Heat-Shock Protein>>HSPA8/HSC70

HSPA8 / HSC70 Alternative Names

HSPA8, HSC70, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, MGC131511, MGC29929, NIP71 [Homo sapiens]

Hspa8, Hsc70, MGC114311 [Mus musculus]

HSPA8 / HSC70 Background

HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised by both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common, but vary in the extent of their inducibility in response to metabolic stress. HSPA8 is constitutively expressed and performs functions related to normal cellular processes. This protein binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. HSPA8 acts as a repressor of transcriptional activation. It inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones. It also is a ATPase that works with auxilin to remove clathrin coated vesicles. In neurons, synaptojanin is also an important protein involved in vesicle uncoating.

HSPA8 / HSC70 Related Studies

1. Santacruz H, et al. (1997) Molecular characterization of a heat shock cognate cDNA of zebrafish, hsc70, and developmental expression of the corresponding transcripts. Dev Genet. 21:223-33.
2. Harhay G P, et al. (2005) Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 6: 166.
3. Goldfarb S, et al. (2006) Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proc Natl Acad Sci. 103(15):5817-22.