HPRG / HRGP Protein & Antibody (HRG)

Histidine-Proline Rich Glycoprotein (Histidine-Rich Glycoprotein)

HPRG / HRGP Products

HPRG / HRGP Protein, Recombinant

Molecule	Species	Description	Cat No
HPRG/HRGP/HRG	Human	HPRG/HRGP/HRG Protein, Recombinant	10836-H08H

HPRG / HRGP Antibody

Molecule	Application	Description	Cat No
Human HPRG/HRGP/HRG	WB, ELISA	Mouse Monoclonal Antibody	10836-MM01
Human HPRG/HRGP/HRG	ELISA	Mouse Monoclonal Antibody	10836-MM02
Human HPRG/HRGP/HRG	WB, ELISA	Rabbit Monoclonal Antibody	10836-R028
Human HPRG/HRGP/HRG	WB, ELISA	Rabbit Polyclonal Antibody	10836-RP03
Human HPRG/HRGP/HRG	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10836-RP04

HPRG / HRGP ELISA Kit

Molecule	Application	Description	Cat No
Human HPRG/HRGP/HRG	ELISA	HPRG/HRGP/HRG ELISA Kit	SEK10836

HPRG / HRGP cDNA Clone

Molecule	Species	Description	Cat No
HPRG/HRGP/HRG	Human	Homo sapiens HPRG/HRGP/HRG cDNA Clone(NM_000412.2)	HG10836-M

HPRG / HRGP Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>HPRG/HRGP/HRG

Immunology>>Innate Immunity>>Coagulation>>HPRG/HRGP/HRG

Cardiovascular>>Coagulation>>HPRG/HRGP/HRG

HPRG / HRGP Alternative Names

HPRG, HRGP, HRG, DKFZp779H1622 [Homo sapiens]

Hprg, Hrgp, Hrg, AI265597, AW413091, D16jh2, D18020 [Mus musculus]

HPRG / HRGP Background

Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets, and contains an unusually large amount of histidine and proline. In human, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

HPRG / HRGP Related Studies

1. Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
2. Doñate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.