Anti-HRG Antibody

Cat: 10836-RP03
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Anti-HRG Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-HRG Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human HRG
Immunogen
Recombinant Human HPRG protein (Catalog#10836-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human HPRG (rhHPRG; Catalog#10836-H08H; Met 1-Lys 525; NP_000403.1). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HRG Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HRG Antibody Alternative Names
Anti-HPRG Antibody;Anti-HRGP Antibody;Anti-THPH11 Antibody
HRG Background Information

Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets, and contains an unusually large amount of histidine and proline. In human, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Full Name
histidine-rich glycoprotein
References
  • Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
  • Doate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HRG Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10836-MM01
    Anti-HRG Antibody Rabbit Monoclonal ELISA 10836-R028
    Anti-HRG Antibody Mouse Monoclonal ELISA 10836-MM23
    Anti-HRG Antibody Mouse Monoclonal ELISA 10836-MM02
    Anti-HRG Antibody Rabbit Polyclonal ELISA 10836-RP04
    info info
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