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HPGD / 15-PGDH Antibody, Rabbit PAb, Antigen Affinity Purified

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Mouse HPGD Antibody Product Information
Immunogen:Recombinant Mouse HPGD / 15-PGDH protein (Catalog#50531-M08E)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse HPGD / 15-PGDH (rM HPGD / 15-PGDH; Catalog#50531-M08E; Q8VCC1; Met 1-Ser 269). HPGD / 15-PGDH specific IgG was purified by Mouse HPGD / 15-PGDH affinity chromatography.
Mouse HPGD Antibody Usage Guide
Specificity:Mouse HPGD / 15-PGDH
Application:WB, ELISA, IP

WB: 5-10 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse HPGD. The detection limit for Mouse HPGD is approximately 0.00975 ng/well.

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse HPGD Antibody WB Application Image
HPGD / 15-PGDH Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Mouse HPGD Antibody IP Application Image
HPGD / 15-PGDH Antibody, Rabbit PAb, Antigen Affinity Purified
Other HPGD Antibody Products
HPGD/15-PGDH Background

Mouse 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.

Mouse HPGD/15-PGDH References
  • Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
  • McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
  • Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
  • Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.
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    Catalog: 50531-RP02-200
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.