Anti-15-PGDH Antibody

Cat: 11205-MM01
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Anti-15-PGDH Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-15-PGDH Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human 15-PGDH
No cross-reactivity in ELISA with E.coli cell lysate
Immunogen
Recombinant Human HPGD protein (Catalog#11205-H08E)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HPGD (rh HPGD; Catalog#11205-H08E; NP_000851.2; Met 1-Gln 266). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #4E2C12E9
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-15-PGDH Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-15-PGDH Antibody Alternative Names
Anti-15-PGDH Antibody;Anti-PGDH Antibody;Anti-PGDH1 Antibody;Anti-PHOAR1 Antibody;Anti-SDR36C1 Antibody
15-PGDH Background Information

15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.

Full Name
hydroxyprostaglandin dehydrogenase 15-(NAD)
References
  • Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
  • McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
  • Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
  • Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-15-PGDH Antibody Rabbit Monoclonal WB,IP 50531-R101
    Anti-15-PGDH Antibody Rabbit Polyclonal ELISA 50531-RP01
    Anti-15-PGDH Antibody Rabbit Monoclonal ELISA 50531-R121
    Anti-15-PGDH Antibody Rabbit Polyclonal WB,ELISA,IP 50531-RP02
    Anti-15-PGDH Antibody Rabbit Monoclonal FCM,ICC/IF,IF 11205-R027
    Anti-15-PGDH Antibody Rabbit Monoclonal FCM,ICC/IF,IF 11205-R016
    Anti-15-PGDH Antibody Rabbit Monoclonal ELISA,ELISA(Det) 11205-R025
    Anti-15-PGDH Antibody (FITC) Rabbit Monoclonal FCM 11205-R027-F
    Anti-15-PGDH Antibody Rabbit Monoclonal ELISA(Cap) 11205-R004
    Anti-15-PGDH Antibody (FITC) Rabbit Monoclonal FCM 11205-R016-F
    Anti-15-PGDH Antibody Mouse Monoclonal WB,ELISA 11205-MM02
    Anti-15-PGDH Antibody Rabbit Polyclonal ELISA 11205-RP01
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