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HNMT Protein, Antibody, ELISA Kit, cDNA Clone

HNMT Related Areas

HNMT Related Pathways

HNMT Related Product

HNMT Summary & Protein Information

HNMT Background

Gene Summary: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
General information above from NCBI
Catalytic activity: S-adenosyl-L-methionine + histamine = S- adenosyl-L-homocysteine + N(tau)-methylhistamine.
Subunit structure: Monomer.
Subcellular location: Cytoplasm.
Sequence similarity: Belongs to the methyltransferase superfamily. HNMT family.C
General information above from UniProt

HNMT Alternative Name

HMT,HNMT,HNMT-S1,HNMT-S2, [human]
AI788969,Hnmt,1500031F01Rik,RP23-263E15.1, [mouse]

HNMT Related Studies

  • Yan L., et al., 2000, Pharmacogenetics 10:261-266.
  • Horton J.R., et al., 2001, Structure 9:837-849.
  • Hillier L.W., et al., 2005, Nature 434:724-731.
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