HMGB1 / HMG1 Protein (SBP-1 Protein)

High-Mobility Group Box 1 (Sulfoglucuronyl Carbohydrate Binding Protein)

HMGB1 / HMG1 Products

HMGB1 / HMG1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
HMGB1/HMG1	Human	HMGB1 / HMG1 / Fc Protein, Recombinant	10326-H01H
HMGB1/HMG1	Human	HMGB1 / HMG1 / Fc Protein, Recombinant	10326-H08H
HMGB1/HMG1	Mouse	HMGB1 / HMG1 Protein, Recombinant	50913-M01H

10326-H01H: The EC₅₀of human HMGB1 is 0.23 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse AGER at 2 µg/mL (100 µl/well) can bind human HMGB1.

10326-H08H: Immobilized human HMGB at 2 µg/ml (100 µl/well) can bind human AGER. The EC₅₀of human AGER is 0.27 µg/ml. Measured by its binding ability in a functional ELISA.

HMGB1 / HMG1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
HMGB1/HMG1	Human	Homo sapiens HMGB1 / HMG1 cDNA Clone(NM_002128.4)	HG10326-M
HMGB1/HMG1	Human	Human HMGB1 / HMG1 ORF Expression Clone, His-tagged	HG10326-M-H
HMGB1/HMG1	Mouse	Mouse HMGB1 / HMG1 cDNA Clone / ORF Clone	MG50913-G

HMGB1 / HMG1 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>HMGB1/HMG1

HMGB1 / HMG1 Alternative Names

HMGB1, HMG1, SBP-1, HMG3, DKFZp686A04236 [Homo sapiens]

Hmgb1, Hmg1, HMG-1, SBP-1, mCG_144566, DEF, MGC103168, MGC103169, MGC117896, MGC117897, amphoterin, p30 [Mus musculus]

HMGB1 / HMG1 Background

High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. It is the prototypic damage-associated molecular pattern (DAMP) molecule and has been implicated in several inflammatory disorders. HMGB1 signals via the receptor for advanced glycation end-product (RAGE) and members of the toll-like receptor (TLR) family. The most prominent HMGB1 protein and mRNA expression arthritis is present in pannus regions, where synovial tissue invades articular cartilage and bone. HMGB1 promotes the activity of proteolytic enzymes, and osteoclasts need HMGB1 for functional maturation. As a non-histone nuclear protein, HMGB1 has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. Extracellular HMGB1 represents an optimal "necrotic marker" selected by the innate immune system to recognize tissue damage and initiate reparative responses. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. HMGB1 has been successfully therapeutically targeted in multiple preclinical models of infectious and sterile diseases including arthritis. As shown in studies on patients as well as animal models, HMGB1 can play an important role in the pathogenesis of rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. In addition, enhanced postmyocardial infarction remodeling in type 1 diabetes mellitus was partially mediated by HMGB1 activation.

HMGB1 / HMG1 Related Studies

Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.
Pisetsky DS, et al. (2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
Volz HC, et al. (2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.
Sims GP, et al. (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.
Andersson U, et al. (2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8.

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