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HMGB1/HMG1 Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli
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10326-H07E-20
10326-H07E-50
20 µg / $178
50 µg / $348
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Description: Active
Expression host: Human Cells
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10326-H01H-20
10326-H01H-50
20 µg / $178
50 µg / $348
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Description: Active
Expression host: Human Cells
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10326-H08H-50
10326-H08H-100
50 µg / $178
100 µg / $298
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Description: Active
Expression host: Human Cells
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50913-M01H-10
50913-M01H-20
10 µg / $158
20 µg / $248
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HMGB1/HMG1  Related Areas

HMGB1/HMG1  Related Pathways

HMGB1/HMG1  Related Product

    HMGB1/HMG1  Summary & Protein Information

    HMGB1/HMG1  Background

    Gene Summary: Activated macrophages and monocytes secrete HMGB1 as a cytokine mediator of Inflammation.[3] Antibodies that neutralize HMGB1 confer protection against damage and tissue injury during arthritis, colitis, ischemia, sepsis, endotoxemia, and systemic lupus erythematosis. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses.
    General information above from NCBI
    Subunit structure: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity).
    Subcellular location: Nucleus. Chromosome.
    Sequence similarity: Belongs to the HMGB family.
    Contains 2 HMG box DNA-binding domains.
    General information above from UniProt

    High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. It is the prototypic damage-associated molecular pattern (DAMP) molecule and has been implicated in several inflammatory disorders. HMGB1 signals via the receptor for advanced glycation end-product (RAGE) and members of the toll-like receptor (TLR) family. The most prominent HMGB1 protein and mRNA expression arthritis is present in pannus regions, where synovial tissue invades articular cartilage and bone. HMGB1 promotes the activity of proteolytic enzymes, and osteoclasts need HMGB1 for functional maturation. As a non-histone nuclear protein, HMGB1 has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. Extracellular HMGB1 represents an optimal "necrotic marker" selected by the innate immune system to recognize tissue damage and initiate reparative responses. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. HMGB1 has been successfully therapeutically targeted in multiple preclinical models of infectious and sterile diseases including arthritis. As shown in studies on patients as well as animal models, HMGB1 can play an important role in the pathogenesis of rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. In addition, enhanced postmyocardial infarction remodeling in type 1 diabetes mellitus was partially mediated by HMGB1 activation.

    HMGB1/HMG1  Alternative Name

    DKFZp686A04236,HMG1,HMG3,HMGB1,SBP-1, [human]
    amphoterin,DEF,Hmg1,HMG-1,Hmgb1,mCG_144566,MGC103168,MGC103169,MGC117896,MGC117897,p30,SBP-1, [mouse]

    HMGB1/HMG1  Related Studies

  • Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.
  • Pisetsky DS, et al. (2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
  • Volz HC, et al. (2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.
  • Sims GP, et al. (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.
  • Andersson U, et al. (2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8.
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