HGFR Protein & Antibody (c-MET)

Hepatocyte Growth Factor Receptor

HGFR Products

HGFR Protein, Recombinant

Molecule	Species	Description	Cat. No
HGFR/c-MET	Human	HGFR/c-MET/Fc Protein, Recombinant	10692-H03H
HGFR/c-MET	Human	HGFR/c-MET Protein, Recombinant	10692-H08H
HGFR/c-MET	Mouse	HGFR/c-MET/Fc Protein, Recombinant	50622-M02H
HGFR/c-MET	Mouse	HGFR/c-MET Protein, Recombinant	50622-M08H
HGFR/c-MET	Canine	HGFR/c-MET Protein, Recombinant	70008-D08H

  10692-H03H: Immobilized recombinant human HGF at 1µg/ml (100µl/well) can bind Human c-MET/HGFR with a linear range of 0.31-160 ng / ml. Measured by its binding ability in a functional ELISA.

  10692-H08H: The EC₅₀ of biotinylated c-Met is 5.28 µg/mL. Measured by its binding ability in a functional ELISA Immobilized recombinant human HGF at 10 µg/ml (100 µl/well) can bind biotinylated c-Met.

  50622-M02H: Measured by its binding ability in a functional ELISA Immobilized human HGF at 2 µg/ml (100 µl/well) can bind mouse HGFR with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

  50622-M08H:  Measured by its ability to compete with mouse C-MET for binding to immobilized human HGF in a functional ELISA assay.

HGFR Antibody

Molecule	Application	Description	Cat. No
Human HGFR/c-MET	WB, ELISA	HGFR/c-MET Antibody, Mouse MAb	10692-MM02
Canine HGFR/c-MET	WB, ELISA	HGFR/c-MET Antibody, Rabbit PAb	70008-RP02

HGFR cDNA Clone

Molecule	Species	Description	Cat. No
HGFR/c-MET	Mosue	Mus musculus HGFR/c-MET cDNA Clone	MG50622-M
HGFR/c-MET	Rat	Rat MET cDNA Clone / ORF Clone	RG80004-M

All HGFR Protein and Antibody

HGFR Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HGFR/c-MET

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>HGFR/c-MET

Cancer>>Cancer Biomarkers>>HGFR/c-MET

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HGFR/c-MET

HGFR Alternative Names

HGFR, c-MET, MET, AUTS9, RCCP2 [Homo sapiens]

HGFR, c-Met, Met, AI838057, HGF, Par4 [Mus musculus]

HGFR Background

Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.

HGFR Related Studies

1. McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
2. Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
3. Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
4. Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.