>Rabbit PAb Antibody
>HGFR / c-MET Antibody (Antigen Affinity Purified)
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HGFR / c-MET Antibody ( Antigen Affinity Purified ) Datasheet
|Order or Inquire for HGFR / c-MET Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
HGFR / c-MET Antibody Product Information
Recombinant Human HGFR / c-MET protein (Catalog#10692-H08H)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
Produced in rabbits immunized with purified, recombinant Human HGFR / c-MET (rh HGFR / c-MET; Catalog#10692-H08H; NP_000236; Met 1-Thr 932). HGFR / c-MET specific IgG was purified by Human HGFR / c-MET affinity chromatography.
HGFR / c-MET Antibody Usage Guide
Human HGFR / c-MET
IHC-P: 0.1-2 μg/mL
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human C-Met.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
HGFR / c-MET Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|HGFR/c-MET||Human||HGFR/c-MET/Fc Protein, Recombinant||10692-H03H|
|HGFR/c-MET||Human||HGFR/c-MET Protein, Recombinant||10692-H08H|
|HGFR/c-MET||Human||c-MET / HGFR (aa 956-1390) Protein, Recombinant, with GST Tag||10692-H20B1|
|HGFR/c-MET||Mouse||HGFR/c-MET/Fc Protein, Recombinant||50622-M02H|
|HGFR/c-MET||Mouse||HGFR/c-MET Protein, Recombinant||50622-M08H|
|HGFR/c-MET||Canine||HGFR/c-MET Protein, Recombinant||70008-D08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||HGFR/c-MET Antibody, Mouse MAb||10692-MM02|
|ELISA, IHC-P||HGFR / c-MET Antibody (Antigen Affinity Purified)||10692-RP02|
|WB, ELISA||HGFR/c-MET Antibody, Rabbit PAb||70008-RP02|
|WB, ELISA||HGFR / c-MET Antibody||70008-MM05|
HGFR / c-MET Antibody Background
The proto-oncogene MET encoded product MET (mesenchymal-epithelial transition factor), also known as c-Met or hepatocyte growth factor receptor (HGFR), is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. As the prototypic member of a small subfamily of growth factor receptors, c-Met/HGFR is synthesized as a single chain precursor, and is processed into a mature disulfide-linked heterodimer composed of a extracellular α subunit and a transmembrane β subunit via post-translational cleavage. c-Met/HGFR is identified as a glycosylated receptor tyrosine kinase (RTK), and HGF is the only known ligand. Following ligand binding and autophosphorylation, c-Met/HGFR transmits intercellular signals using a unique multisubstrate docking site which mediates the binding of multiple SH2-containing adapter proteins such as Grb2, SHC, Crk/CRKL, as well as Gab1. Normal c-Met/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active c-Met/HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. Two transcript variants encoding different isoforms have been identified.
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