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c-MET / HGFR Antibody, Mouse MAb

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Canine c-MET Antibody Product Information
Immunogen:Recombinant Canine HGFR / c-MET protein (Catalog#70008-D08H)
Clone ID:05
Ig Type:Mouse IgG1
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Canine HGFR / c-MET (rCanine HGFR / c-MET; Catalog#70008-D08H; NP_001002963.1; Met 1-Leu 935). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Canine c-MET Antibody Usage Guide
Specificity:Canine HGFR / c-MET
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
Application:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Canine c-MET. The detection limit for Canine c-MET is approximately 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other c-MET Antibody Products
Reactivity: Human  
Application: ELISA  
    10692-T16-100
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          Reactivity: Human  
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            Reactivity: Human  
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            Reactivity: Human  
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            Reactivity: Mouse  
            Application: ELISA  
              50622-RP01-100
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                Reactivity: Cynomolgus  
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                  Reactivity: Canine  
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                        100 µg 
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                        Reactivity: Canine  
                        Application: ELISA  
                          70008-RP01-100
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                          200 µg 
                           
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                          c-Met/Met/HGFR Background

                          Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.

                          Canine c-Met/Met/HGFR References
                        • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
                        • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
                        • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
                        • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.
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                          Catalog: 70008-MM05-50
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                          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"