Anti-c-MET Antibody

Cat: 70008-RP02
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All c-MET Reagents
Anti-c-MET Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-c-MET Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Canine
Specificity
Canine c-MET
Immunogen
Recombinant Canine HGFR / c-MET protein (Catalog#70008-D08H)
Preparation
Produced in rabbits immunized with purified, recombinant Canine HGFR / c-MET (rCanine HGFR / c-MET; Catalog#70008-D08H; NP_001002963.1; Met 1-Leu 935). HGFR / c-MET specific IgG was purified by Canine HGFR / c-MET affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-c-MET Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

c-MET Background Information

Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
MET proto-oncogene, receptor tyrosine kinase
References
  • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
  • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
  • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
  • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 90304-T16
    Anti-c-MET Antibody Mouse Monoclonal ELISA 70008-MM05
    Anti-c-MET Antibody Rabbit Monoclonal ELISA 70008-R202
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 70008-RP01
    Anti-c-MET Antibody Rabbit Monoclonal ELISA 70008-R345
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 50622-RP01
    Anti-c-MET Antibody Rabbit Monoclonal ELISA 50622-R001
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 50622-T16
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 10692-T16
    c-Met / HGFR Neutralizing Antibody Rabbit Monoclonal Neutralization 10692-R615
    Anti-c-MET Antibody (FITC) Rabbit Monoclonal FCM 10692-R271-F
    Anti-c-MET Antibody Rabbit Monoclonal FCM 10692-R271
    Anti-c-MET Antibody Rabbit Polyclonal ELISA 10692-RP01
    Anti-c-MET Antibody Rabbit Monoclonal ELISA(Cap) 10692-R261
    Anti-c-MET Antibody (APC) Rabbit Monoclonal FCM 10692-R243-A
    Anti-c-MET Antibody (APC) Rabbit Monoclonal FCM 10692-R271-A
    Anti-c-MET Antibody Rabbit Monoclonal ELISA 10692-R016
    Anti-c-MET Antibody Rabbit Monoclonal ELISA,FCM 10692-R243
    Anti-c-MET Antibody Rabbit Monoclonal ELISA 10692-R502
    Anti-c-MET Antibody (PE) Rabbit Monoclonal FCM 10692-R243-P
    Anti-c-MET Antibody (FITC) Rabbit Monoclonal FCM 10692-R243-F
    Anti-c-MET Antibody Rabbit Polyclonal WB 100352-T32
    Anti-c-MET Antibody (PE) Rabbit Monoclonal FCM 10692-R271-P
    Anti-c-MET Antibody Mouse Monoclonal ELISA 10692-MM02
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