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c-Met/Met/HGFR Mouse MAb

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    Human c-MET Antibody Product Information
    Immunogen:Recombinant Human c-MET protein (Catalog#10692-H08H)
    Clone ID:1A4G4H7
    Ig Type:Mouse IgG1
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human c-Met (rh c-Met; Catalog#10692-H08H; NP_000236; Met 1-Thr 932). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other c-MET Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10692-T16-100
      10692-T16-200
      10692-T16-50
      100 µg 
      200 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  FCM  
      • Slide 1
      10692-R243-100
      10692-R243-50
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: B/N  
      • Slide 1
      10692-R615-500
      10692-R615-200
      500 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10692-R502-100
        10692-R502-50
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10692-R016-50
          10692-R016-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10692-R243-A-100
          10692-R243-A-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10692-R271-A-100
          10692-R271-A-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10692-R271-100
          10692-R271-50
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10692-RP01-400
            10692-RP01-100
            10692-RP01-200
             
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10692-R271-P-100
            10692-R271-P-50
            100 Tests 
            50 Tests 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10692-R271-F-100
            10692-R271-F-50
            100 Tests 
            50 Tests 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10692-R243-F-100
            10692-R243-F-50
            100 Tests 
            50 Tests 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10692-R243-P-100
            10692-R243-P-50
            100 Tests 
            50 Tests 
            Add to Cart
            Reactivity: Human  
            Application: WB  
            • Slide 1
            100352-T32-200
            100352-T32-100
            100352-T32-50
            200 µg 
            100 µg 
            50 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50622-RP01-100
              50622-RP01-200
              50622-RP01-400
              100 µg 
              200 µg 
               
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50622-T16-100
                50622-T16-50
                50622-T16-200
                100 µg 
                50 µg 
                200 µg 
                Add to Cart
                Reactivity: Cynomolgus  
                Application: ELISA  
                  90304-T16-100
                  90304-T16-50
                  90304-T16-200
                  100 µg 
                  50 µg 
                  200 µg 
                  Add to Cart
                  Reactivity: Canine  
                  Application: ELISA  
                    70008-R345-50
                    70008-R345-100
                    50 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Canine  
                    Application: ELISA  
                      70008-R202-50
                      70008-R202-100
                      50 µg 
                      100 µg 
                      Add to Cart
                      Reactivity: Canine  
                      Application: ELISA  
                        70008-RP02-50
                        70008-RP02-100
                        70008-RP02-200
                        50 µg 
                        100 µg 
                        200 µg 
                        Add to Cart
                        Reactivity: Canine  
                        Application: ELISA  
                          70008-MM05-50
                          70008-MM05-100
                          70008-MM05-200
                          50 µg 
                          100 µg 
                          200 µg 
                          Add to Cart
                          Reactivity: Canine  
                          Application: ELISA  
                            70008-RP01-100
                            70008-RP01-200
                            70008-RP01-400
                            100 µg 
                            200 µg 
                             
                            Add to Cart
                            c-Met/Met/HGFR Background

                            Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.

                            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                            Human c-Met/Met/HGFR References
                          • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
                          • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
                          • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
                          • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.
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                            Catalog: 10692-MM02-50
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                            Datasheet & Documentation

                            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"