Anti-HGF Activator Antibody

Cat: 10329-R101
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Anti-HGF Activator Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-HGF Activator Antibody
Validated applications
Species reactivity
Reacts with: Human
Human HGF Activator
No cross-reactivity in ELISA with Human KLK11
Recombinant Human HGFA protein (Catalog#10329-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human HGFA / HGF Activator (rh HGFA / HGF Activator; Catalog#10329-H08H; NP_001519.1; Met 1-Ser 655).
Monoclonal Rabbit IgG Clone #101
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HGF Activator Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HGF Activator Antibody Alternative Names
Anti-HGFA Antibody;Anti-MGC138395 Antibody;Anti-MGC138397 Antibody;Anti-RP11-529E10.2 Antibody
HGF Activator Background Information

HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.


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2.  Miyazawa, K. et al., 1996, J. Biol. Chem. 271 : 3615-3618.

3.  Shia, S. et al., 2005, J. Mol. Biol. 346: 1335-1349.

4.  Kataoka, H. et al., 2000, J. Biol. Chem. 275: 40453-40462.

5.  Tjin, E.P. et al., 2006, Blood. 107: 760-768.

6.  Kitajima, Y. et al., 2000, Cancer. Res. 60: 6148-6159.

Product Description Host Clonality Application Catalog# (PDF)
Anti-HGF Activator Antibody Mouse Monoclonal ELISA 10329-MM01
Anti-HGF Activator Antibody Rabbit Polyclonal ELISA 10329-RP03
Anti-HGF Activator Antibody Rabbit Polyclonal ELISA 10329-RP02
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