Anti-HGF Activator Antibody

Cat: 10329-RP02
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Anti-HGF Activator Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-HGF Activator Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human HGF Activator
Immunogen
Human cell-derived rhHGFA (Catalog#10329-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human HGFA (rhHGFA; Catalog#10329-H08H; NP_001519.1; Met 1-Ser 655). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HGF Activator Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HGF Activator Antibody Alternative Names
Anti-HGFA Antibody;Anti-MGC138395 Antibody;Anti-MGC138397 Antibody;Anti-RP11-529E10.2 Antibody
HGF Activator Background Information

HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.

References

1.  Shimomura, T. et al., 1993, J. Biol. Chem. 268: 22927-22932.

2.  Miyazawa, K. et al., 1996, J. Biol. Chem. 271 : 3615-3618.

3.  Shia, S. et al., 2005, J. Mol. Biol. 346: 1335-1349.

4.  Kataoka, H. et al., 2000, J. Biol. Chem. 275: 40453-40462.

5.  Tjin, E.P. et al., 2006, Blood. 107: 760-768.

6.  Kitajima, Y. et al., 2000, Cancer. Res. 60: 6148-6159.

Product Description Host Clonality Application Catalog# (PDF)
Anti-HGF Activator Antibody Mouse Monoclonal ELISA 10329-MM01
Anti-HGF Activator Antibody Rabbit Monoclonal ELISA 10329-R101
Anti-HGF Activator Antibody Rabbit Polyclonal ELISA 10329-RP03
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