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HGFA/ HGF activator Antibody, Mouse MAb

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    Human HGFA Antibody Product Information
    Immunogen:Recombinant Human HGFA protein (Catalog#10329-H08H)
    Clone ID:6C2C2G11
    Ig Type:Mouse IgG2a
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HGFA (rhHGFA; Catalog#10329-H08H; NP_001519.1; Met 1-Ser 655). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other HGFA Antibody Products
    HGFA / HGF Activator Background

    HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.

    Human HGFA / HGF Activator References

    1.  Shimomura, T. et al., 1993, J. Biol. Chem. 268: 22927-22932.

    2.  Miyazawa, K. et al., 1996, J. Biol. Chem. 271 : 3615-3618.

    3.  Shia, S. et al., 2005, J. Mol. Biol. 346: 1335-1349.

    4.  Kataoka, H. et al., 2000, J. Biol. Chem. 275: 40453-40462.

    5.  Tjin, E.P. et al., 2006, Blood. 107: 760-768.

    6.  Kitajima, Y. et al., 2000, Cancer. Res. 60: 6148-6159.

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    Catalog: 10329-MM01-200
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"