HGF Protein & Antibody

Hepatocyte Growth Factor

HGF Products

HGF Protein, Recombinant

Molecule	Species	Description	Cat. No
HGF	Human	HGF Protein, Recombinant	10463-H08H
HGF	Human	HGF Protein, Recombinant	10463-HNAC

  10463-H08H:  The ED₅₀ for this effect is typically 5.0 ng/mL in the presence of 1 ng/mL of recombinant human TGF-beta1. Measured by its ability to inhibit TGF-beta1 activity on Mv-1-lu mink lung epithelial cells.

HGF Antibody

Molecule	Application	Description	Cat. No
Human HGF	WB, ELISA	HGF Antibody	10463-RP01
Human HGF	WB, ELISA	HGF / Hepatocyte Growth Factor Antibody (Biotin conjugated)	10463-RP01-B
Human HGF	WB, ELISA	HGF Antibody (Antigen Affinity Purified)	10463-RP02
Human HGF	WB, ELISA	HGF Antibody	10463-RP03
Human HGF	WB, ELISA	HGF Antibody (Antigen Affinity Purified)	10463-RP04

HGF cDNA Clone

Molecule	Species	Description	Cat. No
HGF	Human	Homo sapiens HGF cDNA Clone(NM_000601.4)	HG10463-M
HGF	Mouse	Mus musculus HGF cDNA Clone	MG50038-M

HGF Alternative Names

HGF, HGFB, SF, DFNB39, F-TCF, HPTA [Homo sapiens]

Hgf, HGF/SF, SF/HGF, NK1, NK2, C230052L06Rik [Mus musculus]

HGF Related Areas

Cancer>>Growth Factor & Receptor>>Other>>HGF

HGF Background

Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

HGF Related Studies

1. Naldini L, et al. (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10(10):2867-78.
2. Comoglio, et al. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. 65:131-65.
3. Hahn W, et al. (2011) Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. The Journal of Gene Medicine. 13(10):549-55.
4. Bottaro DP, et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251(4995):802-4.