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HGF / Hepatocyte Growth Factor Antibody, Mouse MAb

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    Human HGF Antibody Product Information
    Immunogen:Recombinant Human HGF / Hepatocyte Growth Factor protein (Catalog#10463-H08H)
    Clone ID:04
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HGF / Hepatocyte Growth Factor (rh HGF / Hepatocyte Growth Factor; Catalog#10463-H08H; NP_000592.3; Met 1-Ser 728). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other HGF Antibody Products
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    10463-RP02-50
    10463-RP02-200
    10463-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    10463-RP04-50
    10463-RP04-200
    10463-RP04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10463-R007-50
      10463-R007-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: B/N  
      • Slide 1
      10463-mh010-500
      10463-mh010-200
      500 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10463-RP01-400
        10463-RP01-200
        10463-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10463-RP03-400
          10463-RP03-200
          10463-RP03-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10463-RP01-B-200
            10463-RP01-B-100
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: ELISA  
              10463-T16-50
              10463-T16-200
              10463-T16-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  IHC-P  
              • Slide 1
              • Slide 1
              50038-T24-50
              50038-T24-200
              50038-T24-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50038-R032-50
                50038-R032-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80429-T16-50
                  80429-T16-200
                  80429-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80429-RP01-400
                    80429-RP01-200
                    80429-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Canine  
                    Application: ELISA  
                      70063-T16-50
                      70063-T16-200
                      70063-T16-100
                      50 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      Reactivity: Canine  
                      Application: ELISA  
                        70063-RP01-400
                        70063-RP01-200
                        70063-RP01-100
                        400 µg 
                        200 µg 
                        100 µg 
                        Add to Cart
                        HGF/Hepatocyte Growth Factor Background

                        Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

                        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                        Human HGF/Hepatocyte Growth Factor References
                      • Naldini L, et al. (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10(10):2867-78.
                      • Comoglio, et al. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. 65:131-65.
                      • Hahn W, et al. (2011) Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. The Journal of Gene Medicine. 13(10):549-55.
                      • Bottaro DP, et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251(4995):802-4.
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                        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"