Anti-HGF Antibody

Cat: 10463-RP02
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Anti-HGF Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-HGF Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human HGF
Immunogen
Recombinant Human HGF protein (Catalog#10463-HNAS)
Preparation
Produced in rabbits immunized with purified, recombinant Human HGF (rh HGF; Catalog#10463-HNAS; NP_000592.3; Met 1-Ser 728). HGF specific IgG was purified by Human HGF affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-HGF Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-HGF Antibody (Rabbit Polyclonal antibody) Images
Human HGF/Hepatocyte Growth Factor Immunohistochemistry(IHC) 4065
Immunochemical staining of human HGF in human cirrhosis with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Anti-HGF Antibody Alternative Names
Anti-DFNB39 Antibody;Anti-F-TCF Antibody;Anti-F-TCFB Antibody;Anti-Hepatocyte Growth Factor Antibody;Anti-HGFB Antibody;Anti-HPTA Antibody;Anti-SF Antibody
HGF Background Information

Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
hepatocyte growth factor (hepapoietin A; scatter factor)
References
  • Naldini L, et al. (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10(10):2867-78.
  • Comoglio, et al. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. 65:131-65.
  • Hahn W, et al. (2011) Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. The Journal of Gene Medicine. 13(10):549-55.
  • Bottaro DP, et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251(4995):802-4.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HGF Antibody Rabbit Monoclonal ELISA 70063-R105
    Anti-HGF Antibody Rabbit Polyclonal ELISA 70063-RP01
    Anti-HGF Antibody Rabbit Polyclonal ELISA 70063-T16
    Anti-HGF Antibody Rabbit Monoclonal ELISA 80429-R052
    Anti-HGF Antibody Rabbit Polyclonal ELISA 80429-T16
    Anti-HGF Antibody Rabbit Polyclonal WB,ELISA,IHC-P 80429-T56
    Anti-HGF Antibody Rabbit Polyclonal ELISA 80429-RP01
    Anti-HGF Antibody Rabbit Polyclonal ELISA,IHC-P 50038-T24
    Anti-HGF Antibody Rabbit Monoclonal ELISA 50038-R032
    Anti-HGF Antibody Rabbit Monoclonal ELISA 10463-R007
    Anti-HGF Antibody Rabbit Polyclonal ELISA 10463-T16
    Anti-HGF Antibody Rabbit Polyclonal ELISA,IHC-P 10463-RP04
    Anti-HGF Antibody Mouse Monoclonal ELISA 10463-MM04
    Anti-HGF Antibody Rabbit Polyclonal ELISA 10463-RP01
    Anti-HGF Antibody Mouse Monoclonal Neutralization 10463-mh010
    Anti-HGF Antibody Rabbit Polyclonal ELISA,IHC-P 10463-T24
    Anti-HGF Antibody (Biotin) Rabbit Polyclonal ELISA 10463-RP01-B
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