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Rhesus HER3 / ErbB3 Protein

  • Rhesus HER3 / ErbB3 Protein SDS-PAGE
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Rhesus ERBB3 Protein Product Information
Synonym:HER3, ErbB3
Protein Construction:A DNA sequence encoding the rhesus ERBB3 (XP_001113953.2) (Met1-Thr643) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Species:Rhesus
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Rhesus ERBB3 Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE.
Bio-Activity:1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rhesus ERBB3 at 10 μg/mL (100 μL/well) can bind Human Fc-NRG1 (isoform Beta1) (Cat:11609-H01H). The EC50 of Human Fc-NRG1 (isoform Beta1) is 0.51-1.19 μg/mL.
Endotoxin:<1.0 EU per μg protein as determined by the LAL method.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ser 20
Molecule Mass:The recombinant rhesus ERBB3 consists 631 amino acids and predicts a molecular mass of 69.5 kDa.
Formulation:Lyophilized from sterile PBS, 10 % Glycerol, 0.01 % Tween 20, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Rhesus ERBB3 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Rhesus ERBB3 Protein SDS-PAGE
Rhesus HER3 / ErbB3 Protein SDS-PAGE

ERBB3 Related Pathways

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ERBB3/HER3 Background

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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Catalog: 90043-KCCH-100
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Datasheet & Documentation

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All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"