HER3 / ERBB3 Protein, Rhesus, Recombinant

Cat: 90043-KCCH
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All HER3 / ERBB3 Reagents
CRO Services
Product recommended

All HER3 / ERBB3 Reagents
HER3 / ERBB3 Protein, Rhesus, Recombinant Product Information
Purity
> 90 % as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rhesus ERBB3 at 10 μg/mL (100 μL/well) can bind Human Fc-NRG1 (isoform Beta1) (Cat:11609-H01H). The EC50 of Human Fc-NRG1 (isoform Beta1) is 0.51-1.19 μg/mL.
Protein Construction
A DNA sequence encoding the rhesus ERBB3 (XP_001113953.2) (Met1-Thr643) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Reference#
Expressed Host
HEK293 Cells
Species
Rhesus
Predicted N Terminal
Ser 20
Molecule Mass
The recombinant rhesus ERBB3 consists 631 amino acids and predicts a molecular mass of 69.5 kDa.
Formulation
Lyophilized from sterile PBS, 10 % Glycerol, 0.01 % Tween 20, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
HER3 / ERBB3 Protein, Rhesus, Recombinant in SDS-PAGE
Rhesus EEBB3/HER3 Protein 12754
HER3 / ERBB3 Background Information

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 3
References
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
  • info info
    添加购物车成功! 添加购物车失败!