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HER3 / ErbB3 Neutralizing Antibody

  • HER3 / ErbB3 Neutralizing Antibody
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Human ERBB3 Antibody Product Information
Immunogen:Recombinant Human HER3 / ErbB3 protein (Catalog#10201-H08H)
Clone ID:mhA24
Ig Type:mouse (varialbe region) / human (kappa / IgG1
Concentration:
Endotoxin:Please contact us for more information.
Formulation:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Preparation:It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Human HER3 / ErbB3. The antibody was produced using recombinant antibody technology.
Human ERBB3 Antibody Neutralization Application Image
HER3 / ErbB3 Neutralizing Antibody
[Click to enlarge image]
Caption:
Cell Proliferation Induced by NRG1-β1/HRG1-β1 was Neutralized by Human ErbB3/Her3 Antibody. Recombinant Human NRG1-1β1/HRG1-1β1 stimulates proliferation in the MCF-7 human breast cancer cell line. Proliferation elicited by Recombinant Human NRG1-1β1/HRG1-1β1 (40 ng/mL) is neutralized by increasing concentrations of Human ErbB3/Her3 Monoclonal Antibody (Catalog 10201-mhA24). The IC50 is typically 5.05-20.2 ng/mL.
Other ERBB3 Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
ERBB3/HER3 Background

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

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Catalog: 10201-mhA24-500
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Datasheet & Documentation

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"