HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human

Cat: SEK10201
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HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human General Information
Product name
HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human HER3 / ERBB3
Assay range
23.44-1500
Materials provided
1. Capture Antibody 0.1 mg/mL of mouse anti-ErbB3 monoclonal antibody, Dilute to a working concentration of 2 μg/mL in CBS before coating. (Catalog: # 10201-MM03)
2. Detection Antibody 0.5 mg/mL of rabbit anti-ErbB3 monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10201-R015)
3. Standard Each vial contains 80 ng of recombinant ErbB3. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve usi ng 2-fold serial dilutions in sample dilution buffer, and a high standard of 1500 pg/mL is recommended.
Product overview
This HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human HER3 / ERBB3 . It contains Human HER3 / ERBB3 capture antibody, Human HER3 / ERBB3 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human HER3 / ERBB3 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human Images
Human EEBB3/HER3 ELISA Pair Set Standard Curve 13807
HER3 / ERBB3 Matched ELISA Antibody Pair Set,Human Alternative Names
c-erbB-3 Matched ELISA Antibody Pair Set, Human;c-erbB3 Matched ELISA Antibody Pair Set, Human;EEBB3 Matched ELISA Antibody Pair Set, Human;ErbB-3 Matched ELISA Antibody Pair Set, Human;erbB3-S Matched ELISA Antibody Pair Set, Human;HER3 Matched ELISA Antibody Pair Set, Human;LCCS2 Matched ELISA Antibody Pair Set, Human;MDA-BF-1 Matched ELISA Antibody Pair Set, Human;p180-ErbB3 Matched ELISA Antibody Pair Set, Human;p45-sErbB3 Matched ELISA Antibody Pair Set, Human;p85-sErbB3 Matched ELISA Antibody Pair Set, Human
HER3 / ERBB3 Background Information

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 3
References
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
  • Product Description Assay Range (pg/ml) Sample Type Catalog# (PDF)
    HER3 / ERBB3 Matched ELISA Antibody Pair Set,Mouse 39.06 pg/ml SEK51003
    HER3 / ERBB3 ELISA Kit, Mouse Serum KIT51003
    HER3 / ERBB3 ELISA Kit, Human Serum KIT10201
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