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ERBB3/HER3 Rabbit PAb , Antigen Affinity Purified

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    Rat ERBB3 Antibody Product Information
    Immunogen:Recombinant Rat HER3 / ErbB3 protein (Catalog#80111-R08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Rat HER3 / ErbB3 (rh HER3 / ErbB3; Catalog#80111-R08H; Q3MHC0; Met1-His641). HER3 / ErbB3 specific IgG was purified by Rat HER3 / ErbB3 affinity chromatography.
    Other ERBB3 Antibody Products
    ERBB3/HER3 Background

    ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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    Catalog: 80111-T16-200
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"