Her2 / ERBB2 cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for three point mutations: 1960 A/G resulting in the amino acid 654Ile substitution by Val, 1963 A/G resulting in the amino acid 655Ile substitution by Val and 3508 C/G resulting in the amino acid 1170Pro substitution by Ala.
Description
Full length Clone DNA of Human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), transcript variant 1.
Plasmid
Vector
pMD18-T Simple Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Her2 / ERBB2 cDNA ORF Clone in Cloning Vector, Human Alternative Names
CD340 cDNA ORF Clone, Human;HER-2 cDNA ORF Clone, Human;HER-2/neu cDNA ORF Clone, Human;HER2 cDNA ORF Clone, Human;MLN 19 cDNA ORF Clone, Human;MLN19 cDNA ORF Clone, Human;NEU cDNA ORF Clone, Human;NGL cDNA ORF Clone, Human;TKR1 cDNA ORF Clone, Human
Her2 / ERBB2 Background Information
Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Full Name
erb-b2 receptor tyrosine kinase 2
References
Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
