Quick Order

HER2 / ErbB2 / CD340 Antibody, Rabbit MAb

  • HER2 / ErbB2 / CD340 Antibody, Rabbit MAb, Immunohistochemistry
  • Human HER2/ERBB2 Immunohistochemistry(IHC) 14786
  • HER2 / ErbB2 / CD340 Antibody, Rabbit MAb, Flow cytometric
  • HER2 / ErbB2 / CD340 Antibody, Rabbit MAb, Flow cytometric
DatasheetReviewsRelated ProductsProtocols
Human ErbB2/HER2 Antibody Product Information
Immunogen:Recombinant Human ErbB2 protein (Catalog#10004-H20B1)
Clone ID:002
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human ErbB2 / HER2 cytoplasmic domain (rhErbB2; Catalog#10004-H20B1; NP_004439.2; Lys 676-Val 1255).
Human ErbB2/HER2 Antibody IF Application Image
HER2 / ErbB2 / CD340 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunofluorescence staining of Human ErbB2 in SKBR3 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human ErbB2 monoclonal antibody ( 10 µg/ml ) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody ( green ) and counterstained with DAPI ( blue ). Positive staining was localized to plasma membrane.
Other ErbB2/HER2 Antibody Products
Immunochemical staining of human SELPLG in human tonsil with mouse monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
HER2/ERBB2 Background

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human HER2/ERBB2 References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Product nameProduct name
    Size / Price
    Catalog: 10004-R002-50
    List Price: 
    Price:      (You Save: )
    Size:
    50 µg
    100 µg
    Quantity:+-
    AvailabilityIn Stock
    Add to CartBulk Discount Inquiry

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"